Refresh energy & revamp metabolism
Mito Metabolism Blend helps enhance mitochondrial function, reduce oxidative stress, and promote cellular health and longevity from the inside out. It combines SS-31 and NAD+; two compounds that target mitochondrial function from complementary angles, with SS-31 protecting the structural integrity of the mitochondrial inner membrane and NAD+ restoring the coenzyme activity that powers the electron transport chain.
Administered as a subcutaneous injection five mornings per week, Mito Metabolism is designed for patients focused on cellular energy, metabolic fatigue, and long-term mitochondrial and cognitive health.
The information provided on this page is for general informational purposes only and is not a substitute for professional medical advice. Always follow your RegenMD provider’s precise prescription and consult them directly with any questions or concerns. Not all patients qualify for every treatment—book a consultation to determine the best option for you.
Mito Metabolism is administered as a subcutaneous (SubQ) injection, with a 30G/31G syringe at the prescribed dosage.
Mito Metabolism targets the mitochondria; the organelles responsible for generating virtually all of the body's usable energy. When mitochondrial function declines through oxidative damage, membrane deterioration, or coenzyme depletion, the downstream effects include persistent fatigue, cognitive sluggishness, and reduced metabolic efficiency. SS-31 and NAD+ address the two primary mechanisms underlying this decline: membrane structural integrity and the coenzyme availability that drives energy production.
SS-31 is a mitochondria-targeted antioxidant tetrapeptide with a unique ability to selectively accumulate within the inner mitochondrial membrane. Its mechanism centers on binding to cardiolipin; a phospholipid found almost exclusively in the inner mitochondrial membrane that is essential to the function of the electron transport chain complexes responsible for ATP synthesis. Oxidative stress damages cardiolipin, disrupting the structural architecture of the inner membrane and reducing the efficiency of electron transfer and energy production.
SS-31 protects cardiolipin from this oxidative damage, preserving the membrane's integrity and the efficiency of the mitochondrial machinery it supports. This cardiolipin-protective mechanism also underlies SS-31's cardioprotective and neuroprotective properties; cardiac and neuronal cells have the highest mitochondrial density in the body and are most vulnerable to mitochondrial dysfunction.
NAD+ provides the electron-carrying capacity that the electron transport chain requires to convert nutrients into ATP. Within the context of Mito Metabolism, its role is specifically to ensure that the restored mitochondrial architecture supported by SS-31 has the coenzyme substrate it needs to operate at full capacity.
NAD+ also activates sirtuins; a class of proteins that regulate mitochondrial biogenesis, the process by which cells generate new mitochondria, and that modulate the oxidative stress responses operating alongside SS-31's protective mechanism. The two compounds are mutually reinforcing: SS-31 preserves the mitochondrial structure, NAD+ fuels it.
Mito Metabolism is administered as a subcutaneous injection five mornings per week over a five or ten-week program. Your RegenMD provider establishes dosing based on your metabolic profile and wellness goals, and monitors your response throughout.
Mito Metabolism is a physician-prescribed peptide protocol combining SS-31 and NAD+ to address mitochondrial function at both the structural and biochemical level. SS-31 protects the inner mitochondrial membrane from oxidative damage; NAD+ provides the coenzyme substrate that powers the electron transport chain and activates the cellular repair proteins that depend on it. The protocol is administered five mornings per week over a five or ten-week program and is designed for patients focused on cellular energy, metabolic resilience, and cognitive clarity.
SS-31 selectively accumulates within the inner mitochondrial membrane, where it binds to cardiolipin; a phospholipid unique to that membrane and critical to the structural organization of the electron transport chain complexes that generate ATP. Oxidative stress degrades cardiolipin, which destabilizes the membrane architecture and reduces energy production efficiency. By protecting cardiolipin from oxidative damage, SS-31 preserves the structural integrity of the mitochondrial inner membrane and sustains the efficiency of the ATP synthesis process that every cell in the body depends on.
Cardiolipin is a phospholipid found almost exclusively in the inner mitochondrial membrane. It plays a structural role in organizing the protein complexes of the electron transport chain and is essential to their proper function. When cardiolipin is damaged by reactive oxygen species, the architecture of these complexes deteriorates; energy production drops, oxidative stress increases, and the mitochondria enter a cycle of declining function. SS-31's specific binding to cardiolipin interrupts this cycle at its structural source rather than addressing oxidative stress broadly.
Standalone NAD+ therapy focuses on restoring coenzyme levels to support the electron transport chain, sirtuin activation, DNA repair, and overall cellular energy metabolism.
Mito Metabolism adds SS-31, which addresses the structural layer of mitochondrial function that NAD+ alone cannot reach.
Where NAD+ ensures the fuel and repair machinery are available, SS-31 ensures the mitochondrial infrastructure they depend on is protected and intact. Patients with more pronounced mitochondrial dysfunction, metabolic fatigue, or cardiovascular stress may benefit from the combined structural and biochemical approach the blend provides.
Mito Metabolism is well-suited for patients experiencing persistent energy deficits, cognitive fatigue, or afternoon energy crashes that resist correction through lifestyle changes; those with high metabolic demand or physiological stress loads; individuals focused on cardiovascular and neurological health at the cellular level; and patients interested in longevity-focused protocols targeting mitochondrial function specifically. Your RegenMD provider will assess your metabolic profile during your evaluation to determine whether Mito Metabolism is the right fit.
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