Sculpt muscle & shred fat
Define Stack is a high-potency peptide protocol designed to sculpt your body, burn visceral fat, and support body recomposition from the inside out. It combines IGF-1, Sermorelin, and Tesamorelin; each targeting a distinct aspect of body composition through growth hormone stimulation, visceral fat reduction, and lean tissue preservation in a single coordinated protocol.
Administered as a subcutaneous injection five evenings per week, Define Stack is designed for patients looking to reduce visceral fat and support body composition through a hormonally precise approach; dosing is tailored to your individual hormonal profile.
The information provided on this page is for general informational purposes only and is not a substitute for professional medical advice. Always follow your RegenMD provider’s precise prescription and consult them directly with any questions or concerns. Not all patients qualify for every treatment—book a consultation to determine the best option for you.
Define Stack is administered as a subcutaneous (SubQ) injection, with a 30G/31G syringe at the prescribed dosage.
Engineered for body recomposition, Define Stack combines IGF-1, Sermorelin, and Tesamorelin in a protocol that targets visceral fat reduction, lean tissue support, and growth hormone optimization through coordinated, complementary mechanisms. Each ingredient contributes a distinct function; the protocol is more targeted as a result than any single compound could achieve on its own.
IGF-1, known scientifically as insulin-like growth factor 1, is produced naturally in the liver in response to growth hormone signaling. It plays a central role in lean tissue preservation, supporting the body's ability to maintain and repair tissue during periods of caloric restriction or metabolic demand. IGF-1 also promotes the body's utilization of stored fat as an energy source, supports bone density, and contributes to cognitive and vascular health; its presence in the Define Stack protocol ensures that fat reduction does not come at the expense of tissue integrity.
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to increase its own natural production of human growth hormone. Operating through the body's existing feedback loop rather than bypassing it, Sermorelin raises growth hormone levels in a physiologically regulated way. Within Define Stack, Sermorelin provides the hormonal foundation for the protocol; elevated natural HGH supports fat metabolism, deepens sleep quality, and enhances the regenerative conditions that make the other compounds more effective.
Tesamorelin is a stabilized GHRH analog with a clinically demonstrated specificity for visceral adipose tissue reduction. Visceral fat accumulates deep in the abdominal cavity around internal organs; it is metabolically active, hormonally disruptive, and typically resistant to diet and exercise alone. Tesamorelin stimulates growth hormone release through mechanisms that produce a pronounced and targeted effect on visceral fat metabolism, making it the most specifically focused compound in the Define Stack protocol for abdominal recomposition.
Define Stack is administered as a subcutaneous injection five evenings per week, timed to align with the body's natural nocturnal growth hormone secretion cycle. Your RegenMD provider establishes your dosing protocol based on your hormonal profile and body composition goals, and monitors your response across the five or ten-week program.
Define Stack is a physician-prescribed peptide blend of IGF-1, Sermorelin, and Tesamorelin. These three compounds are formulated to address the hormonal and metabolic factors governing body composition and visceral fat simultaneously. Administered as a subcutaneous injection five evenings per week over a five or ten-week program, it is designed as a comprehensive body recomposition protocol rather than a single-mechanism fat loss tool.
Tesamorelin is a stabilized GHRH analog with clinically demonstrated selectivity for visceral adipose tissue. Unlike subcutaneous fat, visceral fat is deeply embedded around internal organs, metabolically active, and resistant to conventional interventions. Tesamorelin stimulates growth hormone release through mechanisms that specifically affect visceral fat metabolism; its selectivity for this fat depot distinguishes it from general growth hormone-stimulating compounds and makes it central to the Define Stack formulation.
Both protocols involve growth hormone-stimulating compounds, but they serve different primary goals. Performance Blend uses CJC-1295 and Ipamorelin to support overall vitality, cardiovascular health, and recovery. Define Stack incorporates Tesamorelin's visceral fat-targeting mechanism alongside IGF-1's tissue preservation and metabolic support; the entire protocol is calibrated for patients whose primary objective is body recomposition and visceral fat reduction rather than general wellness optimization.
The body secretes its largest natural growth hormone pulse during the first phase of deep sleep. Administering GHRH analogs like Sermorelin and Tesamorelin before bed amplifies this existing nocturnal pulse rather than working against the body's hormonal rhythm. Morning administration would miss the primary growth hormone secretion window; evening dosing is a deliberate and clinically reasoned component of the Define Stack protocol.
Sleep quality and energy improvements are typically among the first changes patients notice, generally within the first two to four weeks. Measurable shifts in body composition, particularly reductions in visceral fat and improved definition, become evident between weeks six and ten.
A full ten-week program produces the most comprehensive results; some patients continue to see improvement in the weeks following program completion as the hormonal environment remains elevated. Individual outcomes vary based on adherence, nutrition, activity level, and baseline hormonal status.
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