Focus Blend , a clear mix of peptides in liquid form against a dark grey backdrop.
A close-up shot of a woman's eye indicates improved focus.
Focus Blend , a clear mix of peptides in liquid form against a dark grey backdrop.
A close-up shot of a woman's eye indicates improved focus.
Sharpen & Chill

Focus Blend

Sharpen focus & revive motivation

Focus Blend uses powerful neural enhancers; including the nootropic compounds PE-22-28, Pinealon, and Selank; to support memory, sharpen focus, and elevate mood. PE-22-28 targets serotonin channel pathways governing mood and motivation, Pinealon supports pineal gland function and neuroprotection, and Selank modulates the GABAergic system to reduce the stress-driven cognitive interference that undermines clear thinking.

Administered as a subcutaneous injection five mornings per week, Focus Blend is designed for daytime use to align with active cognitive demands; dosing is personalized to your cognitive profile and wellness goals.
Focus Blend
  • Overview
  • Specifications
  • Improves memory, learning ability, and new neural connections
  • Acts as a natural antidepressant
  • Improves motivation
  • Improves the brain's stress resilience
  • May increase serotonin levels
  • Promotes healthy circadian rhythm and improves sleep
  • Preserves cognitive performance amidst stress
  • Boosts mood
  • Improves overall brain function
  • PE-22-28
  • Pinealon
  • Selank
  • 20IU SubQ
  • Monday-Friday (a.m.)
  • 5 or 10 weeks

Focus is administered as a subcutaneous (SubQ) injection, with a 30G/31G syringe at the prescribed dosage.

Injection Tutorial

How Focus Blend Works

Three neurological pathways converge in Focus Blend to address the conditions that most reliably disrupt sustained mental performance. PE-22-28 targets serotonin channel regulation at the TREK-1 level to support mood and motivation, Pinealon governs the pineal gland's role in circadian timing and neuroprotection, and Selank modulates the GABAergic and serotonergic systems to reduce the anxiety and stress that actively interfere with focus and memory. Each mechanism is distinct; the protocol is more comprehensive as a result.

PE-22-28 is a synthetic analog of spadin, a naturally occurring neuropeptide derived from TREK-1 potassium channel proteins. TREK-1 channels play a significant role in regulating serotonin availability in the brain; PE-22-28 modulates their activity to enhance serotonergic signaling in regions associated with mood, motivation, and emotional regulation. Its mechanism operates at the channel level rather than by inhibiting serotonin reuptake, making it a fundamentally different approach to serotonin-based mood and focus support. Research also indicates PE-22-28 supports hippocampal neurogenesis, contributing to the formation of new neural connections that underpin learning and memory consolidation.

Pinealon is a tripeptide derived from pineal gland tissue with a primary function in supporting the gland's regulation of melatonin synthesis and the body's circadian clock. By maintaining the precision of sleep-wake timing, it supports the quality of overnight cognitive restoration that makes sustained daytime focus possible. Pinealon also provides neuroprotective activity within brain tissue; it shields neurons from oxidative stress and supports the structural integrity of pathways involved in attention, learning, and memory.

Selank contributes to the Focus Blend protocol through GABAergic and serotonergic modulation that produces a sustained anxiolytic effect without sedation or cognitive blunting. Chronic stress and anxiety generate neurological interference that disrupts working memory, attention, and the serotonin signaling enhanced by PE-22-28; Selank normalizes this neurochemical environment, allowing the other compounds in the protocol to operate without resistance.

Focus Blend is administered as a subcutaneous injection five mornings per week, timed for daytime use to align with peak cognitive demand periods. Your RegenMD provider establishes dosing based on your cognitive profile and goals, and monitors your response across the five or ten-week program.

What This Means For You

  • Sharpens mental clarity and sustained focus
  • Improves memory retention and learning capacity
  • Regulates mood through serotonin channel mechanisms
  • Reduces anxiety and stress without sedation
  • Promotes healthy circadian rhythm and sleep quality
  • Neuroprotective support for long-term brain health
  • Strengthens motivation and emotional resilience
  • Optimizes serotonin metabolism

Frequently Asked Questions

Focus Blend is RegenMD's physician-prescribed nootropic protocol combining PE-22-28, Pinealon, and Selank to target the neurological factors that most commonly undermine sustained mental performance: mood dysregulation, circadian disruption, and chronic stress. Each compound addresses one of these through a distinct brain mechanism, and the protocol is formulated specifically for daytime use across a five or ten-week program.

TREK-1 is a potassium channel expressed in serotonin-producing neurons; its activity directly governs how much serotonin is available for neurotransmission in mood and motivation centers of the brain. PE-22-28 modulates TREK-1 to enhance serotonergic signaling without inhibiting reuptake, making it mechanistically distinct from conventional approaches to serotonin support. Research also suggests PE-22-28 promotes hippocampal neurogenesis, supporting the formation of new neural connections involved in learning and memory.

Pinealon is a tripeptide derived from pineal gland tissue that supports the gland's regulation of melatonin production and the body's internal circadian clock. Its circadian support improves the quality of overnight neural restoration that directly affects daytime cognitive performance; without adequate circadian regulation, focus, memory, and emotional stability all suffer. Pinealon also provides neuroprotective activity in brain tissue, protecting neurons from oxidative damage and supporting the structural health of pathways central to sustained attention.

Both protocols include Selank and support brain health, but they target different primary objectives.

Cognitive Blend pairs Semax with Selank to drive performance through BDNF elevation, neuroplasticity, and dopaminergic enhancement.

Focus Blend adds PE-22-28 and Pinealon to address serotonin channel health, circadian rhythm support, and the kind of sustained, emotionally regulated focus that stress and disrupted sleep specifically undermine. Patients with mood variability, circadian dysfunction, or stress-driven cognitive impairment may find Focus Blend more specifically suited to their situation.

Selank's anxiolytic effects are typically among the first noticed, with many patients reporting reduced anxiety and improved emotional steadiness within the first one to two weeks. PE-22-28's mood and serotonergic contributions build progressively, with clearer improvements in motivation and focus generally apparent by weeks two to four. Pinealon's circadian and neuroprotective benefits accumulate across the full program. Some patients report that cognitive and mood benefits persist beyond the end of the protocol as neuroplastic and circadian changes consolidate.

Getting Started Is Easy

Step 1: Consultation

A consultation to explore your goals, answer questions, and outline your wellness plan.

Step 2: Evaluation

Meet with a provider for a personalized evaluation and tailored peptide treatment plan.

Step 3: Activation

Finalize your order, receive treatment details, and begin your wellness journey.

Book a Consulation